In adults, each network exhibited strong positive correlations within-network, and strong negative correlations across network
Results, Inter-region correlation analysis, paragraph 2; Figure 2
What the paper reports
- within-ToM against across-network: paired sample two-tailed t-test, t(32) = 19.1, p < 2.2 × 10⁻¹⁶ (n = 33 adults)
- within-Pain against across-network: paired sample two-tailed t-test, t(32) = 23.2, p < 2.2 × 10⁻¹⁶ (n = 33 adults)
Main reading (O1 all voxels of the deposited masks, O2a, O3a). Adult means within-ToM .604, within-Pain .398, across -.051; paired t within-ToM against across 19.1 and within-Pain against across 21.8, both p < 1e-18. The two t values are in tolerance under three of the four O2 and O3 readings; the three means are out of tolerance under all. O1 with only voxels with data gives identical values. Variants outside the paper's method (no high-pass, 50 s high-pass, no CompCor) give adult means from .556 to .645 within-ToM and -.051 to .059 across, none near the paper's. Further diagnostic variants, adults (within-ToM, within-Pain, across), are mean r in place of z .519, .354, -.049; the high-pass basis in the nuisance regression .593, .393, -.086; left and right M1 as two regressors .599, .390, -.037; and the mean ToM and Pain signal as an added regressor .286, .258, -.382. Only the last, which is not the paper's method, moves the across value past the paper's, and it also takes both within-network values well below the paper's (.286 and .258 against .48 and .35). A shared signal removed in the paper's processing would shift the across value in this direction, but this variant does not match the paper's pattern, and no step of the Methods accounts for the offset. The ROI masks are in MNI mm (9 mm sphere centroids within 3.7 mm of the stated centers, every voxel within 8.9 mm), and the images are int16 with no scaling. Fig. 2 shows the mean matrices only as colours, so the offset cannot be traced pair by pair; the adult and 3yo mean matrices are printed in the notebook.
How the test differed from the paper’s method
- The 100 s high-pass filter is SPM's discrete cosine basis (spm_filter); the Methods say SPM8 and "a cutoff of 100 s" without naming the filter. A standard choice.
- The cleaning is applied to the ROI mean timecourse, which equals cleaning each voxel and averaging, as every step of Methods paragraph 4 is linear and the same for each voxel.