Claims 40
From the paper 10.1038/s41531-025-01070-4 · claims file · checked 2026-10-21: ready
- fig1-network-size
The simulated M1 network is composed of 10,073 neurons of seven excitatory pyramidal cell types (IT, PT5B, CT) and two interneuron cell types (PV, SOM).
Simulated primary motor cortex (M1) is composed of 10,073 neurons.
Figure 1 legend; Methods, Microcircuit composition, paragraph 1How it will be judged
In each of the four files of set sM1_12-12-2023, count the units whose population is one of the 15 M1 populations of sim/cfg.py (allpops), leaving out the input spike generators. Reproduced when the count is 10,073 in each file. The tolerance is zero because the number is a count of a fixed model, not a measurement.
- model-pt5b-excitability-decrease
In the parkinsonian condition the PT5B neuron model was changed (BK and NaT conductances) so that its spike count across current injections fell by 64%, as in 6-OHDA mouse slices.
In the simulated parkinsonian mouse M1 PT5B currents (BK and NaT) were modified so that they showed a 64% decrease in excitability as reported by Chen et al.
Methods, paragraph 2 and Morphology and physiology of neuron classes, paragraph 3; Supplementary Fig. 1 (not read)How it will be judged
Needs single-neuron current-injection simulations of the control and parkinsonian PT5B model (README parameter settings; cfg.gpeak and cfg.gnafbar). The current amplitudes, step duration and averaging behind the 64% are those of Fig. 1D of Chen et al. 2021 (J. Neurosci. 41, 5553) and Supplementary Fig. 1, which was not available to this reader. The claim can be tested only if the dataset holds these current-injection simulations and the supplement or the question process supplies the protocol; otherwise the detail is open and the claim is blocked as methods_underspecified.
- robustness-four-sets
The results hold across four sets of four simulations with different random seeds; set sM1_12-12-2023 is a typical example and the other three sets are analysed in Supplementary Table 2.
To demonstrate robustness, we ran 4 sets of 4 simulations (Supplementary Table 2 ), each set including the control and parkinsonian conditions in rest state and in the activated (movement) state.
Methods, paragraph 2; Supplementary Table 2 and Supplementary Figs. 2 to 5 (not read)How it will be judged
Supplementary Table 2, which gives the measures and values for the other three sets, was not in the text supplied, so this reader cannot fix the measures, the expected values or what counts as holding. The claim is blocked as methods_underspecified until a reader with the supplement completes it. The author may report, for each set the dataset holds, the measures of the claims below, without an outcome.
- fig2-control-rest-beta
In the control condition at rest, M1 activity is dominated by beta-band activity of about 20 Hz, particularly clear in the PT5B spike count histogram.
Resting state (250 ms at midpoint of 4.3 s simulation) displayed dominant beta-band activity (~20 Hz; particularly clear in the PT5B spike count histogram).
Figure 2A legend; Results, Control simulations, paragraph 1How it will be judged
File -01. The frequency of the largest peak of the time-averaged power spectrum in W of (a) the PT5B SCH (the legend's measure) and (b) the LFP under E1 and E2. The paper reports separate 2 Hz activity in the rest LFP (Fig. 3A), so the peak is searched (i) above 0 Hz and (ii) above 5 Hz, a range the paper does not fix. Reproduced when the peak is within 18 to 22 Hz under every reading of the SCH; the LFP readings are reported as variants, since the legend names the SCH.
- fig2-control-activated-gamma
In the control condition, the activated state shifts M1 activity to gamma-band activity of about 44 Hz.
Activated state showed change to high-frequency gamma-band activity (~44 Hz).
Figure 2B legend; Results, Control simulations, paragraph 1How it will be judged
File -03, the measure and readings of fig2-control-rest-beta. Reproduced when the largest spectral peak of the PT5B SCH in W is within 39.6 to 48.4 Hz under every reading; the LFP readings (E1, E2) are reported as variants.
- fig2c-control-pt5b-rate-activated
In the control condition PT5B neurons fire more in the activated state than at rest (11.7 +/- 9.4 against 26.8 +/- 18.2 spikes/s, p < 0.001).
Pyramidal tract neurons had the highest spike rate of any neuron population during the rest state, and increased further in the activated state (rest: 11.7 ± 9.4 spikes/s; activated: 26.8 ± 18.2 spikes/s; p < 0.001; Fig. 2C ).
Figure 2C legend; Results, Control simulations, paragraph 5How it will be judged
Files -01 and -03, rates in W, readings R1 and R2. Reproduced when, under one rate reading, all four values are within tolerance and the activated rates are higher with p < 0.001 under every test reading T1 to T4.
- fig2c-control-it23-rate-activated
In the control condition IT2/3 neurons fire more in the activated state than at rest (1.2 +/- 1.6 against 6.7 +/- 8.9 spikes/s, p < 0.001).
IT2/3 neurons significantly increased their firing rate (rest: 1.2 spikes/s; activated: 6.6 spikes/s; p < 0.001).
Figure 2C legend; Results, Control simulations, paragraph 5How it will be judged
Files -01 and -03, population IT2, rates in W, readings R1 and R2. The legend gives 6.7 and the text 6.6 spikes/s for the activated mean; the tolerance of 6.7 covers both. Reproduced when, under one rate reading, all four values are within tolerance and the activated rates are higher with p < 0.001 under every test reading T1 to T4.
- fig2c-control-it6-rate-activated
In the control condition IT6 neurons fire less in the activated state than at rest (5.8 +/- 5.8 against 3.5 +/- 5.2 spikes/s, p < 0.001).
IT6 firing rates decreased from 5.8 spikes/s at rest to 3.5 spikes/s in the activated state ( p < 0.001).
Figure 2C legend; Results, Control simulations, paragraph 5How it will be judged
Files -01 and -03, rates in W, readings R1 and R2. Reproduced when, under one rate reading, all four values are within tolerance and the activated rates are lower with p < 0.001 under every test reading T1 to T4.
- control-it5-silenced-activated
In the control condition IT5A and IT5B neurons fire at about 3 spikes/s at rest (3.3 and 3.1 spikes/s) and stop firing (0 spikes/s) in the activated state.
In contrast, IT5A and IT5B firing rates decreased from 3 Hz (IT5A... 3.3 spikes/s; IT5B... 3.1 spikes/s) at rest, to 0 spikes/s in the activated state
Results, Control simulations, paragraph 5; Figure 2BHow it will be judged
Files -01 and -03, rates in W, reading R1 (under R2 an activated mean is undefined when no neuron fires; if some fire, R2 is reported as a variant). The tolerance of the zero rates is 0.05 spikes/s, the rounding of the paper's one decimal place, since 10% of zero is zero. Reproduced when all four values are within tolerance.
- control-it4-rate-activated
In the control condition the IT4 population rate rises from 2.6 spikes/s at rest to 4.7 spikes/s in the activated state.
The IT4 neuron population firing rate increased from 2.6 Hz during rest to 4.7 Hz during the activated state.
Results, Control simulations, paragraph 5How it will be judged
Files -01 and -03, rates in W, readings R1 and R2. Reproduced when, under one reading, both values are within tolerance. The paper reports no test.
- pt5b-highest-rate
PT5B neurons have the highest mean spike rate of any population in the control rest state and in both the parkinsonian rest and activated states.
Pyramidal tract neurons had the highest spike rate of any neuronal population during the rest and activated states in the parkinsonian condition
Results, Control simulations, paragraph 5; Results, Parkinsonian condition, paragraph 5How it will be judged
Files -01, -02 and -04, mean rates in W of every M1 population. "Any neuron population" can be read as (a) all 15 M1 populations, interneurons included, or (b) the seven excitatory pyramidal cell types (Methods, Morphology and physiology of neuron classes, paragraph 1), the excitatory cell types of Figs. 2C and 5C. Reproduced when the PT5B mean is the highest in all three simulations under one rate reading (R1 or R2) and both population readings; when the population readings disagree, the claim is blocked as methods_underspecified with both shown.
- control-cv-isi
In the control condition PT5B interspike-interval CV is highly variable at rest (0.59 +/- 0.37; 47.8% regular with CV <= 0.5, 52.2% irregular) and mainly irregular in the activated state (0.61 +/- 0.30; 25.7% regular, 74.3% irregular).
The CV was found to be highly variable across the PT5B population during rest (0.59 + /−0.37), indicating the presence of both regular (CV < = 0.5; 47.8%) and irregular activity (CV > 0.5; 52.2%).
Results, Control simulations, paragraph 2How it will be judged
Files -01 and -03. CV of each PT5B neuron's ISIs (standard deviation over mean), mean and standard deviation over neurons, and the share with CV <= 0.5 (regular) and > 0.5 (irregular), as in the Results. Open, with readings - the window, (a) W (the window of the rates in the same figure) or (b) the whole 4.3 s; which neurons, (i) neurons with at least two ISIs or (ii) at least one ISI (a single ISI gives CV 0). Reproduced when, under one combination of readings, all six values are within tolerance.
- control-subthreshold-oscillations
In the control condition subthreshold membrane-potential oscillations appear in 57.4% of PT5B neurons in the activated state and not at rest.
Oscillations in subthreshold membrane potentials appeared frequently during the activated state (57.4% of PT5B neurons) but not during rest
Results, Control simulations, paragraph 3; Figure 2A,BHow it will be judged
Files -01 and -03, somatic membrane potentials of the PT5B neurons recorded. Neither the paper nor its code says how a subthreshold oscillation is detected or over which neurons the 57.4% is taken, and no reading follows from the text. The claim is blocked as methods_underspecified unless a question to a reader settles it; the number of PT5B neurons with recorded voltage is reported.
- control-duty-cycle
In the control condition the PT5B duty cycle, the share of each oscillation period with activity above half-height, is 31% at rest and 48% in the activated state.
The duty cycle was 31% during rest (Fig. 2A ) and 48% during activated state (Fig. 2B ; dashed vertical lines not shown).
Results, Control simulations, paragraph 4; Figure 2A,B; Methods, Duty cycleHow it will be judged
Files -01 and -03, the PT5B SCH (2 ms bins, unsmoothed, as the legends describe it). A period runs from one rising crossing of half-height to the next, and the duty cycle is the time above half-height divided by the period (Results, paragraph 4; the Methods sentence that a period runs from the rising to the falling crossing would make every duty cycle 100% and is read as defining the time on). Open, with readings - half-height, (a) halfway between the minimum and maximum of the window shown (one line per panel, Fig. 2 legend) or (b) halfway between the trough and peak of each period (Methods); the window, (i) the 250 ms of Fig. 2A,B, 2.0 to 2.25 s (the notebooks) or (ii) W; the summary over periods, which the paper does not give, (x) the mean of the per-period duty cycles or (y) the total time above half-height over the total time of complete periods. Reproduced when, under one combination, both values are within tolerance.
- fig3a-control-rest-spectrogram
In the control rest state the LFP spectrogram shows virtually continuous power around 2 Hz and 15 to 25 Hz beta bursts recurring every 600 ms (1.7 Hz).
The rest state simulation revealed virtually continuous power around 2 Hz, as well as 15–25 Hz beta-band bursts (Fig. 3A ), occurring every 600 ms (or with a burst-rate of 1.7 Hz).
Figure 3A legend; Results, Control simulations, paragraph 6How it will be judged
File -01, LFP spectrogram in W, readings S1, S2 and E1, E2. Power around 2 Hz is present when the time-averaged spectrum has a local maximum within 1 to 3 Hz, the reading of "power around 2 Hz" as a spectral peak. The paper does not define a burst. The one reading the paper's text offers is its own half-height convention (Methods, Duty cycle) applied to the 15 to 25 Hz band power over time - a burst is an epoch above halfway between the minimum and maximum of that band power in W. Reproduced when the 2 Hz peak is present and the burst rate is within tolerance under every reading; the author may ask a reader for a burst definition.
- fig3b-control-activated-spectrogram
In the control activated state the 2 Hz activity disappears, 15 to 20 Hz power is no longer visible except 15 Hz bursts of about 100 to 500 ms at about 1.5 Hz, and brief (about 50 ms) 25 to 35 Hz bursts occur at about 1 Hz.
During the activated state the 2 Hz activity disappeared and beta bursts shifted to 15 Hz bursts ~100–500 ms in duration or about 1.5 Hz. Beta-band power between 15–20 Hz was no longer visible (Fig. 3B ).
Figure 3B legend; Results, Control simulations, paragraph 6How it will be judged
File -03 against file -01, the spectrogram readings and the 2 Hz and burst readings of fig3a-control-rest-spectrogram, with 15 Hz bursts taken in the 14 to 16 Hz band (a band this reader chose; the paper gives no width) and 25 to 35 Hz bursts in that band. Reproduced when the time-averaged spectrum has no local maximum within 1 to 3 Hz, the mean 15 to 20 Hz power is lower than at rest, the burst rates and the median 25 to 35 Hz burst duration are within tolerance and the 15 Hz burst durations fall within 90 to 550 ms (the reported range widened by 10% of each bound), under every reading.
- control-coincident-spikes
In the control condition 1% of PT5B spikes are coincident with another PT5B spike within 1 ms at rest, and 3% in the activated state.
PT5B spike coincident firing was observed in 1% of spikes at rest and increased to 3% during the activated state
Results, Control simulations, paragraph 7; Figure 4How it will be judged
Files -01 and -03, PT5B spikes. A spike is coincident when another PT5B neuron fires "within a 1 ms time window" (Results, paragraph 7). Open, with readings - (a) a spike of another PT5B neuron within 1 ms either side, or (b) a spike of another PT5B neuron in the same 1 ms bin ("2 or more spikes firing in 1 ms", Results, Parkinsonian condition, paragraph 7); the window, (i) W, (ii) 0.3 to 4.3 s or (iii) 0 to 4.0 s (the unitary-event analysis covers 4.0 s, Fig. 4 legend, and the paper does not say which). Reproduced when, under one combination, both values are within tolerance.
- fig4-control-unitary-events
In the control condition, PT5B coincident firing above that expected from rate-matched Poisson processes occurs at rest in 100 to 275 ms clusters with 15 to 24 Hz periodicity (mean 19 Hz), totalling 0.7 of 4.0 s (17.5%), and in the activated state in more frequent 125 to 250 ms clusters totalling 1.1 of 4.0 s (27.5%).
The total duration of significant synchronous activity increased from 0.7 s out of 4.0 s (17.5%) at rest to 1.1 s out of 4.0 s (27.5%).
Figure 4B,D legends; Results, Control simulations, paragraph 7How it will be judged
Files -01 and -03, all PT5B spikes. Unitary event analysis (Methods, Identifying synchronous spiking; Grün et al. 1999 and 2002, refs. 77, 24, 87) - coincidences are 2 or more PT5B spikes within 1 ms; the expected count comes from Poisson processes matched to the neurons' rates in a 100 ms window (Fig. 4D legend); a window is significant when the joint-surprise p < 0.05; significant periods are the union of significant windows. Open, with readings - window placement, (a) 100 ms windows slid in 1 ms steps or (b) non-overlapping 100 ms windows; the 4.0 s analysed, (i) 0.3 to 4.3 s or (ii) 0 to 4.0 s; the periodicity of a significant period, (x) the peak of the PT5B SCH spectrum within it or (y) the inverse of the mean interval between SCH peaks. Reproduced when, under one combination, the three values are within tolerance, the rest cluster durations fall within 90 to 302.5 ms and the activated within 112.5 to 275 ms (reported ranges widened by 10% of each bound), and the activated state has more significant periods than rest.
- fig5-pd-rest-beta
In the parkinsonian condition at rest, M1 activity shows focused beta-band activity at 15 Hz.
Resting state (250 ms shown at midpoint of 4.3 s simulation) displayed focused 15 Hz beta-band activity.
Figure 5A legend; Results, Parkinsonian condition, paragraph 1How it will be judged
File -02, the measure and readings of fig2-control-rest-beta. Reproduced when the largest spectral peak of the PT5B SCH in W is within 13.5 to 16.5 Hz under every reading; the LFP readings (E1, E2) are reported as variants.
- fig5-pd-activated-gamma
In the parkinsonian condition the activated state shifts M1 activity to gamma-band activity of about 43 Hz.
Activated state showed change to high-frequency gamma-band activity (~43 Hz).
Figure 5B legend; Results, Parkinsonian condition, paragraph 1How it will be judged
File -04, the measure and readings of fig2-control-rest-beta. Reproduced when the largest spectral peak of the PT5B SCH in W is within 38.7 to 47.3 Hz under every reading; the LFP readings (E1, E2) are reported as variants. The Results (Parkinsonian condition, paragraph 1) give ~44 Hz for the LFP excursions; the tolerance covers both numbers.
- fig5c-pd-pt5b-rate-activated
In the parkinsonian condition PT5B neurons fire more in the activated state than at rest (14.2 +/- 7.1 against 29.7 +/- 12.7 spikes/s, p < 0.001).
Pyramidal tract neurons had the highest spike rate of any neuronal population during the rest and activated states in the parkinsonian condition (rest: 14.2 ± 7.1 spikes/s; activated: 29.7 ± 12.7 spikes/s; p < 0.001; Fig. 5C ).
Figure 5C legend; Results, Parkinsonian condition, paragraph 5How it will be judged
Files -02 and -04, rates in W, readings R1 and R2. Reproduced when, under one rate reading, all four values are within tolerance and the activated rates are higher with p < 0.001 under every test reading T1 to T4.
- fig5c-pd-it23-rate-activated
In the parkinsonian condition IT2/3 neurons fire more in the activated state than at rest (0.78 +/- 1.1 against 4.3 +/- 7.1 spikes/s, p < 0.001).
In contrast, superficial layer IT2/3 neurons significantly increased their average firing rates with activation (rest: 0.8 spikes/s; activated: 4.3 spikes/s; p < 0.001).
Figure 5C legend; Results, Parkinsonian condition, paragraph 5How it will be judged
Files -02 and -04, population IT2, rates in W, readings R1 and R2. Reproduced when, under one rate reading, all four values are within tolerance and the activated rates are higher with p < 0.001 under every test reading T1 to T4.
- pd-it5-silenced-activated
In the parkinsonian condition IT5A and IT5B neurons fire at 2.2 and 1.2 spikes/s at rest and stop firing (0 spikes/s) in the activated state.
IT5A and IT5B firing rates decreased from 2.2 and 1.2 spikes/s, respectively, at rest to 0 spikes/s in the activated state.
Results, Parkinsonian condition, paragraph 5How it will be judged
Files -02 and -04, as in control-it5-silenced-activated. Reproduced when all four values are within tolerance.
- pd-it6-rate-unchanged
In the parkinsonian condition the IT6 firing rate does not change with activation (6.0 spikes/s at rest and in the activated state).
The firing rates of IT6 neurons did not change (rest and activated: 6.0 spikes/s).
Results, Parkinsonian condition, paragraph 5How it will be judged
A claim of absence. Files -02 and -04, IT6 rates in W, readings R1 and R2. The paper names neither the test nor the threshold for this comparison; its other rate comparisons use bounds down to p < 0.05, so the threshold is p < 0.05 and the test readings are T1 to T4. Reproduced when both means are within tolerance under one rate reading and no test reading finds a difference at p < 0.05; not reproduced when a test does. The difference of means and every p-value are reported.
- pd-cv-isi
In the parkinsonian condition PT5B spiking is mainly regular at rest (CV 0.34 +/- 0.27; 80.6% with CV <= 0.5) and more regular in the activated state (CV 0.18 +/- 0.19; 93.8% regular).
In the activated state, PT5B population analysis showed regular spiking that included a small number of irregular spiking neurons (CV 0.18 + /- 0.19; 93.8% CV < = 0.5 regular; 6.2% CV > 0.5 irregular).
Results, Parkinsonian condition, paragraph 2How it will be judged
Files -02 and -04, the measure and readings of control-cv-isi. Reproduced when, under one combination of readings, all six values are within tolerance.
- pd-no-subthreshold-oscillations
No subthreshold membrane-potential oscillations are seen in PT5B neurons in the parkinsonian rest or activated states.
No subthreshold membrane potential oscillations were observed in the parkinsonian rest or active states.
Results, Parkinsonian condition, paragraph 3; Figure 5A,BHow it will be judged
Files -02 and -04, with the detection rule of control-subthreshold-oscillations, which the paper does not give. Blocked as methods_underspecified with that claim unless a question settles the rule; then reproduced when no recorded PT5B neuron meets it in either state.
- pd-activated-vm-more-negative
In the activated state, PT5B membrane potential is on average more negative in the parkinsonian than in the control condition, which the paper gives as the reason the EPSPs look larger.
Activated state EPSPs appear larger in the parkinsonian in contrast with the control condition due to the greater driving force on EPSP since, on average, the membrane potential is more negative in the parkinsonian condition with its reduced excitability.
Results, Parkinsonian condition, paragraph 3How it will be judged
Files -03 and -04, somatic membrane potential of the PT5B neurons recorded in both, in W. The paper gives no measure. Readings (a) the mean of each neuron's trace, spikes included, and (b) its median, which spikes barely move. Reproduced when the mean over neurons is lower in the parkinsonian file under both readings; the per-neuron differences are reported.
- pd-duty-cycle
In the parkinsonian condition the PT5B duty cycle is 29% at rest and 25% in the activated state.
The duty cycle was 29% during the parkinsonian rest state (Fig. 5A ) and 25% during activated state (Fig. 5B ; dashed vertical lines not shown).
Results, Parkinsonian condition, paragraph 4; Figure 5A,B; Methods, Duty cycleHow it will be judged
Files -02 and -04, the measure and readings of control-duty-cycle. Reproduced when, under one combination, both values are within tolerance.
- fig6a-pd-rest-spectrogram
In the parkinsonian rest state the LFP spectrogram shows continuous high-power 15 Hz beta with 25 to 35 Hz bursts of about 50 to 250 ms recurring about every 200 ms (about 5 Hz).
LFP spectrograms of resting oscillatory power displayed continuous high-power 15 Hz beta-band power with bursts of power in the ~25–35 Hz (~50–250 ms duration) occurring about once every 200 ms (~5.0 Hz; Fig. 6A ).
Figure 6A legend; Results, Parkinsonian condition, paragraph 6How it will be judged
File -02, spectrogram readings S1, S2 and E1, E2 in W, bursts as in fig3a-control-rest-spectrogram in the 25 to 35 Hz band. "Continuous" 15 Hz power is read with the same half-height convention - the 14 to 16 Hz band power stays above halfway between its minimum and maximum in W for at least 90% of the time, a share the paper does not give (the 90% is this reader's, so it is reported, not decisive). Reproduced when the burst rate is within tolerance and the burst durations fall within 45 to 275 ms (reported range widened by 10% of each bound) under every reading; the share of time the 15 Hz band is above half-height is reported.
- fig6b-pd-activated-spectrogram
In the parkinsonian activated state the LFP spectrogram shows 20 to 35 Hz bursts of about 25 to 100 ms recurring every 50 to 100 ms (about 10 to 20 Hz).
In the activated state, ~20–35 Hz bursts ~25–100 ms in duration were seen that occurred every ~50–100 ms (~10–20 Hz; Fig. 6B ).
Figure 6B legend; Results, Parkinsonian condition, paragraph 6How it will be judged
File -04, the readings of fig6a-pd-rest-spectrogram, bursts in the 20 to 35 Hz band. Reproduced when, under every reading, the burst rate is within 9 to 22 Hz and the median burst duration within 22.5 to 110 ms (the reported ranges widened by 10% of each bound).
- pd-coincident-spikes
In the parkinsonian condition 2% of PT5B spikes are coincident (2 or more spikes in 1 ms) at rest and 3% in the activated state.
PT5B spike coincident firing (2 or more spikes firing in 1 ms) was observed in 2% of spikes at rest and increased to 3% during the activated state
Results, Parkinsonian condition, paragraph 7; Figure 7How it will be judged
Files -02 and -04, the measure and readings of control-coincident-spikes. Reproduced when, under one combination, both values are within tolerance.
- fig7-pd-unitary-events
In the parkinsonian condition, significant PT5B coincident firing occurs at rest in 400 to 1100 ms clusters of 6 to 16 periods at 14 to 15 Hz (mean 15 Hz), totalling 3.1 of 4.0 s (77.5%), and in the activated state in 100 to 350 ms epochs totalling 1.4 of 4.0 s (35.0%).
The total duration of significant synchronous activity during rest was 3.1 s out of 4.0 s (77.5%). During the activated state, 1.4 s of 4.0 s (35.0%), was significantly synchronous.
Figure 7B,D legends; Results, Parkinsonian condition, paragraph 7How it will be judged
Files -02 and -04, the method and readings of fig4-control-unitary-events. Reproduced when, under one combination, the three values are within tolerance, the rest cluster durations fall within 360 to 1210 ms and the activated within 90 to 385 ms (reported ranges widened by 10% of each bound).
- rest-pt5b-rate-pd-vs-control
At rest, PT5B firing rate is higher and less variable in the parkinsonian than in the control condition (14.2 +/- 7.1 against 11.7 +/- 9.4 spikes/s, p < 0.001), a paradoxical increase given the reduced PT5B excitability.
The most substantial changes in firing between conditions were seen in the simulated rest state, where there was a significant increase in PT5B firing rate and a decrease in firing rate variability in the parkinsonian condition as compared with control condition (control: 11.7 ± 9.4 spikes/s; parkinsonian: 14.2 ± 7.1 spikes/s; p < 0.001).
Results, Control vs parkinsonian comparison, paragraph 1; Discussion, paragraph 1How it will be judged
Files -01 and -02, rates in W, readings R1 and R2, with the expected values of the two claims it depends on. Reproduced when, under one rate reading, the four rest values are within tolerance, the parkinsonian mean is higher with p < 0.001 under every test reading T1 to T4 (paired readings pair neurons by index, the network being the same), and the parkinsonian standard deviation is lower. The paper names no test of the variability; the standard deviations are compared as numbers.
- rest-it4-rate-pd-vs-control
At rest, IT4 firing rate is higher in the parkinsonian than in the control condition (14.1 against 2.6 spikes/s, p < 0.05).
There was also an increase in IT4 firing rate (control: 2.6 spikes/s; parkinsonian: 14.1 spikes/s; p < 0.05)
Results, Control vs parkinsonian comparison, paragraph 1How it will be judged
Files -01 and -02, rates in W, readings R1 and R2. Reproduced when, under one rate reading, both values are within tolerance and the parkinsonian rate is higher with p < 0.05 under every test reading T1 to T4.
- rest-it5a-rate-pd-vs-control
At rest, IT5A firing rate is lower in the parkinsonian than in the control condition (2.2 against 3.3 spikes/s, p < 0.01).
a decrease in IT5A firing rate (control: 3.3 spikes/s; parkinsonian: 2.2 spikes/s; p < 0.01)
Results, Control vs parkinsonian comparison, paragraph 1How it will be judged
Files -01 and -02, rates in W, readings R1 and R2. Reproduced when, under one rate reading, both values are within tolerance and the parkinsonian rate is lower with p < 0.01 under every test reading T1 to T4.
- activated-pt5b-rate-pd-vs-control
In the activated state, PT5B firing rate is higher and less variable in the parkinsonian than in the control condition (29.7 +/- 12.7 against 26.8 +/- 18.2 spikes/s, p < 0.001).
Activated (movement-associated) cortical dynamics also showed a significant increase in PT5B firing rate and a decrease in firing rate variability in the parkinsonian condition as compared with control condition (control: 26.8 ± 18.2 spikes/s; parkinsonian: 29.7 ± 12.7 spikes/s; p < 0.001).
Results, Control vs parkinsonian comparison, paragraph 1How it will be judged
Files -03 and -04, as in rest-pt5b-rate-pd-vs-control, with the four activated values. The Discussion (paragraph 1) says the opposite, that there was no significant change in PT5B population firing rate in the activated state; this claim follows the Results, which give the numbers, and the outcome under every test reading is reported for both.
- activated-it6-rate-pd-vs-control
In the activated state, IT6 firing rate is higher in the parkinsonian than in the control condition (6.0 against 3.5 spikes/s, p < 0.001).
The firing rate of IT6 neurons also increased in the parkinsonian condition (control: 3.5 spikes/s; parkinsonian: 6.0 spikes/s; p < 0.001).
Results, Control vs parkinsonian comparison, paragraph 1How it will be judged
Files -03 and -04, rates in W, readings R1 and R2. Reproduced when, under one rate reading, both values are within tolerance and the parkinsonian rate is higher with p < 0.001 under every test reading T1 to T4.
- rest-beta-power-order-of-magnitude
At rest, LFP beta power around 15 Hz is an order of magnitude larger in the parkinsonian than in the control condition.
In the resting state, an order of magnitude increase in beta power was observed around 15 Hz.
Discussion, paragraph 3; Figures 3A and 6A (colour bars x 10^-5 and x 10^-4)How it will be judged
Files -01 and -02, LFP in W, readings S1, S2 and E1, E2. The paper shows the increase by the colour scales of Figs. 3 and 6 and gives no band; "around 15 Hz" is read as (a) the power at 15 Hz and (b) the mean power over 14 to 16 Hz, a band centred on 15 Hz that the paper does not give (the parkinsonian rest periodicity of Results, Parkinsonian condition, paragraph 7, is 14 to 15 Hz). The ratio of time-averaged parkinsonian to control power is computed. "An order of magnitude" is read as a ratio that rounds to 10 on a log scale, from 10^0.5 (3.16) to 10^1.5 (31.6), since the paper gives no number. Reproduced when the ratio lies in that range under every reading; not reproduced when it is below 3.16 under every reading.
- activated-20-35hz-power-pd-vs-control
In the activated state, the parkinsonian condition shows more power at 20 to 35 Hz than the control condition.
Parkinsonism-associated changes were less marked in the activated (movement) state, where we found no significant change in PT5B population firing rate but did see a change in PT5B activity pattern with an increase in power of 20–35 Hz activity
Discussion, paragraph 1; Figures 3B and 6BHow it will be judged
Files -03 and -04, LFP in W, readings S1, S2 and E1, E2, and the PT5B SCH spectrum (the sentence speaks of PT5B activity, the figures of the LFP). The paper gives no size or test. Reproduced when the mean 20 to 35 Hz power is higher in the parkinsonian file under every reading; the ratios are reported.
- rest-synchrony-increase
At rest, PT5B spike synchrony is substantially larger in the parkinsonian than in the control condition (significant synchrony 3.1 against 0.7 of 4.0 s).
We found a substantial increase in synchronous spiking in our simulations of the parkinsonian rest state.
Discussion, paragraphs 1 and 6; Figures 4B and 7BHow it will be judged
Files -01 and -02, the unitary-event method and readings of fig4-control-unitary-events. Reproduced when the total duration of significant synchrony at rest is larger in the parkinsonian file under every reading; the durations come from the two claims it depends on, with their expected values.
Pipeline
- Paper
- done (1 of 1)
- Claims
- done
- Claims check
- done (ready)
- Attempt
- todo
- Questions
- none
- Verified
- none